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German Researchers Identify Potential drug for Covid-19

Scientists at the German Primate Center – Leibniz Institute for Primate Research have found that an existing drug may help treat Covid-19.

As well as Charité – Universitätsmedizin Berlin, the scientists worked with researchers at the University of Veterinary Medicine Hannover Foundation, the BG-Unfallklinik Murnau, the LMU Munich, the Robert Koch Institute and the German Center for Infection Research.

The research aimed to understand the entry of the novel coronavirus, SARS-CoV-2, into host cells, as well as determine approaches to block the process.

Research findings showed that SARS-CoV-2 requires cellular protein TMPRSS2 to enter hosts’ lung cells.

German Primate Center Infection Biology Unit head Stefan Pöhlmann said: “Our results show that SARS-CoV-2 requires the protease TMPRSS2, which is present in the human body, to enter cells. This protease is a potential target for therapeutic intervention.”

Coronavirus patients died in China

Furthermore, the team observed that the drug camostat mesilate, known to act against TMPRSS2, could block novel coronavirus infection, offering promise for a new treatment option (Cell).

Camostat has approval in Japan for the treatment of pancreatic inflammation.

When tested on SARS-CoV-2 isolated from a patient, camostat blocked the entry of the virus into lung cells, noted the researchers.

Study lead author Markus Hoffmann added: “We have tested SARS-CoV-2 isolated from a patient and found that camostat mesilate blocks entry of the virus into lung cells.

“Our results suggest that camostat mesilate might also protect against COVID-19. This should be investigated in clinical.





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